The state of the vasomotor function of the endothelium in persons exposed to various radiation doses in the long-term follow-up period (a clinical and ultrasound study)
- 14.00.05
Description
The dissertation examines the vasomotor function of the endothelium in persons exposed to radiation at different doses in the remote period after irradiation. The work is of a clinical and ultrasound character and is aimed at assessing the state of peripheral vessels, in particular the brachial artery, using tests of endothelium-dependent and endothelium-independent vasodilation. The study includes groups with different histories of radiation exposure, including participants in the liquidation of the consequences of the Chernobyl AES accident, and analyzes baseline parameters of the artery diameter and blood flow, as well as vascular responses to functional loads.
Table of contents
- Abbreviations in the text
- INTRODUCTION
- 1. REVIEW OF THE LITERATURE
- 2. MATERIALS AND METHODS
- 2.1. Characteristics of the clinical comparison groups
- 2.2. Methods of examination, processing and analysis of the results
- 3. RESULTS OF THE STUDY
- 3.1. General characteristics of the peripheral vessels and baseline parameters of the brachial artery diameter and blood flow in the comparison groups
- 3.2. Results of the study of endothelium-dependent vasodilation of the brachial artery in the comparison groups
- 3.3. Results of the study of endothelium-independent vasodilation of the brachial artery and changes in intraluminal flow during the nitroglycerin test in the comparison groups
- 3.4. Clinical examples
- 4. DISCUSSION OF THE RESULTS
- CONCLUSIONS
- REFERENCES
- ABBREVIATIONS IN THE TEXT
- AH — arterial hypertension
- AES — atomic electric station
- GB — hypertensive disease
- GNTs RF-IBF — State Scientific Center of the Russian Federation — Institute of Biophysics
- GKh — hypercholesterolemia
- DEP — discirculatory encephalopathy
- IBS — coronary heart disease
- LZh — left ventricle
- LPA — liquidation of the consequences of the accident
- MZ RF — Ministry of Health of the Russian Federation
- NGKh — hereditary hypercholesterolemia
- NDF — diastolic function disturbance
- OBA — common femoral artery
- OLB — acute radiation sickness
- OON — United Nations Organization
- OSA — common carotid artery
- PA — brachial artery
- REG — rheoencephalography
- SN — heart failure
- SSZ — cardiovascular diseases
- SSS — cardiovascular system
- TKM — bone marrow transplantation
- TTO — total therapeutic irradiation
- ULPA — participant in the liquidation of the consequences of the accident
- FV — ejection fraction
- FUMBEP — Federal Department for Medical, Biological and Extreme Problems
- ChAÉS — Chernobyl Atomic Electric Station
- EKG — electrocardiography
- EkhokG — echocardiography
- EAG — essential arterial hypertension
Questions and answers
- What radiation doses are considered in the study?
- The study covers persons exposed to radiation at different doses in the remote follow-up period; specific dose ranges are not indicated in the provided materials.
- What methods were used to assess endothelial function?
- Ultrasound methods for examining the brachial artery were used, including assessment of baseline diameter and blood flow parameters, an endothelium-dependent vasodilation test, and a nitroglycerin test for endothelium-independent vasodilation.
- What comparison groups were formed in the work?
- Clinical comparison groups with different histories of radiation exposure were formed, including liquidators of the consequences of the Chernobyl AES accident; a detailed characterization of the groups is given in Section 2.1.
- What clinical parameters were evaluated along with ultrasound data?
- Along with the ultrasound assessment of vessels, general clinical and instrumental methods were applied, including electrocardiography, echocardiography, and assessment of cardiovascular risk factors, as reflected in the sections devoted to the characteristics of the groups and the methods of examination.
- What is the practical significance of the obtained results?
- The results expand the understanding of the vasomotor function of the endothelium in the remote period after irradiation and can be used to improve clinical follow-up of persons exposed to radiation at different doses.